At Loose Ends: Resecting a Double-Strand Break
نویسندگان
چکیده
منابع مشابه
At Loose Ends: Resecting a Double-Strand Break
Double-strand break (DSB) repair is critical for maintaining genomic integrity and requires the processing of the 5' DSB ends. Recent studies have shed light on the mechanism and regulation of DNA end processing during DSB repair by homologous recombination.
متن کاملCatching a (Double-Strand) Break: The Rad51 and Dmc1 Strand Exchange Proteins Can Co-occupy Both Ends of a Meiotic DNA Double-Strand Break
Broken DNA can be repaired by homologous recombination mechanisms, which initially align both ends of a DNA double-strand break (DSB) with a homologous repair template. Particularly in the context of a crowded eukaryotic nucleus, it remains mysterious how the two ends of a broken DNA molecule coordinate their actions to identify an appropriate template and initiate repair. In this issue, Brown ...
متن کاملProcessing of Dna Double-strand Break Ends and Telomere Ends in Fission Yeast
INTRODUCTION. DNA double-strand break (DSB) ends and telomere ends should be handled differently, because DSB ends should be joined, but telomere ends should not be joined. Recent studies have revealed that several proteins involved in DNA repair such as Mre11 complex and Ku heterodimer are also required for telomere maintenance. But how these proteins carry out different tasks at two different...
متن کاملDouble strand break repair.
DNA double-strand breaks (DSBs) are the most dangerous form of DNA damage and can lead to death, mutation, or malignant transformation. Mammalian cells use three major pathways to repair DSBs: homologous recombination (HR), classical nonhomologous end joining (C-NHEJ), and alternative end joining (A-NHEJ). Cells choose among the pathways by interactions of the pathways with CtIP and 53BP1. HR i...
متن کاملDNA Repair: A RIDDLE at a Double-Strand Break
Ubiquitin is known to accumulate at the sites of DNA damage. The identification of a new ubiquitin ligase, RIDDLIN, provides evidence for a ubiquitin-signalling cascade that regulates the assembly of an important DNA repair complex at a DNA double-strand break.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2009
ISSN: 0092-8674
DOI: 10.1016/j.cell.2009.05.007